Abstract:EMBL has released the latest annual update to its cornerstone resource, the AlphaFold Protein Structure Database (AFDB). This update not only expands the number of high-precision protein structure predictions to hundreds of millions but also introduces a completely redesigned interactive 3D browser. This tool enables in-depth interpretation of protein isoforms, Multiple Sequence Alignments (MSA), and interactions between proteins, nucleic acids, and small molecules. The core value of this version lies in its significantly improved accuracy in predicting ligand-receptor binding mechanisms, directly accelerating global efforts in drug target identification, enzyme engineering, and defense against emerging infectious diseases.

Link: https://alphafold.ebi.ac.uk/